Prurigo Nodularis onset during secukinumab treatment of psoriasis: a case report.

BACKGROUND: Secukinumab has been approved by the U.S. FDA and the European Medicines Agency for the treatment of moderate-to-severe plaque psoriasis and psoriatic arthritis with the documented adverse effects. Here we reported in one case that a new symptom, Prurigo Nodularis (PN), developed during the programmed dosing of secukinumab. CASE INTRODUCTION: A 22-years-old male with a 6-month history of severe plaque psoriasis vulgaris was presented to the dermatology clinic two weeks after the fifth serial weekly doses of secukinumab, for the reason of the outbreaks of multiple erythematous papules and pruritus nodules on the trunk and extremities. Physical examination showed that psoriatic rash were under effective control with the previous targeted therapy of secukinumab for plaque psoriasis vulgaris, but new dermatologic condition was spotted with multiple edematous red firm papules on the trunk and extremities, in the form of soy or hemispherical nodules, red in color, firm to touch, with some ulcerated crusts visible at tops, but negative Auspitz sign. Pathological examination confirmed these papules as PN. CONCLUSION: This case report is shared to inform clinicians about an unannounced adverse effect of the secukinumab in the treatment of psoriasis, and it is recommended that patients be carefully informed of the possible risk of PN before starting treatment.

Analysis of related factors affecting hemoporfin-mediated photodynamic therapy for port-wine stain: A retrospective study.

BACKGROUND: Hemoporfin-mediated photodynamic therapy (HMME-PDT) is currently considered one of the most promising therapies for port-wine stain (PWS). However, the efficacy of this is very variable and needs further studies. METHODS: A total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME-PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed. RESULTS: The efficacy of HMME-PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1/2/last session (p < .05). The number of treatments was associated with efficacy, and patients who received more than two sessions had a better response than those who underwent two sessions only (p < .001). Ordinal logistic regression analysis confirmed the above-mentioned associations. Nevertheless, patients of different sex, subtype, and lesion size showed no significant differences. CONCLUSIONS: Our studies demonstrated that HMME-PDT is effective in the treatment of PWS. The more prior PDL treatments, older age, lips involvement, PWS on limbs were adverse factors for Hemoporfin-PDT, while multiple HMME-PDT sessions can improve effective and response rate. Besides, ambient temperature and lesions temperature should be concerned, local cooling provides some relief from pain but may influence effect.

Acupuncture-exacerbated pyoderma gangrenosum associated with IgG multiple myeloma.

INTRODUCTION: PG is an uncommon, noninfectious neutrophilic dermatosis. Very few cases of bullous PG as the first manifestation of IgG myeloma have been reported. HE4, a novel marker for human cancers, may be a promising marker of bone destruction and disease progression in patients with hematologic malignancies and PG lesions. CASE REPORT: The authors report a case of a 49-year-old female who presented with painful patches located on the lower extremities for the past 5 months, and then had lesions that rapidly progressed to necrotic ulcers after unregulated acupuncture therapy. During the treatment procedure, underlying IgG κ-type myeloma was diagnosed. After the diagnosis was confirmed, the patient underwent chemotherapy, and the lesions started to heal and gradually showed scarring. The current report also discusses the potential value of HE4 as applied to malignancies that present with PG and bone destruction. CONCLUSIONS: Once the diagnosis of the underlying systemic disease is confirmed, patients with PG should simultaneously receive aggressive treatment for the primary disease. More emphasis should be put on HE4 regarding the progression of monoclonal gammopathy-related PG with bone destruction to provide new ideas to understand the pathogenesis of this disease.

Hematoporphyrin monomethyl ether-mediated photodynamic therapy for phakomatosis pigmentovascularis type â ¡: A case report.

Phakomatosis pigmentovascularis (PPV) is a rare congenital syndrome characterized by capillary malformation (mainly port-wine stains, PWS) and pigmentary nevi with or without extracutaneous signs. Efforts are ongoing to develop laser therapy to treat vascular and pigmentation abnormalities in PPV. The status of pulsed-dye lasers in the treatment of PWS has been challenged by vascular-targeted photodynamic therapy (PDT). Hematoporphyrin monomethyl ether-mediated PDT (HMME-PDT) has become a research hotspot for PWS. The long-term efficiency and safety of HMME-PDT for vascular lesions coexisting with pigmented lesions in PPV have not been reported. We report a pediatric case of PPV type Ⅱa presenting with PWS and nevus of Ota efficiently treated through a 3-session HMME-PDT. After treatment, the PWS lesions regressed significantly without noticeable adverse reactions or recurrence. Besides, we share the dermoscopy data of PPV lesions and discuss the clinical manifestations and therapeutic strategies for PPV based on existing related literature.

Molding processed multi-layered and multi-functional nanocomposites with high structural ability, electrical conductivity and durable superhydrophobicity.

Bioinspired superhydrophobic surfaces are mainly attributed to nano/micro textures and low surface energy materials, and have exciting potential for use in fields such as self-cleaning, water-proofing, anti-icing, anti-fouling, and so forth. However, the natural weakness of such delicate hierarchical surface structures pose great challenges to using artificial superhydrophobic surfaces under harsh mechanical conditions. Completely transforming multi-layered composite materials with good structural ability into superhydrophobic surfaces would greatly extend their durability under continuous mechanical abrasion. Endowing these composites with electrical conductivity could further expand their scope of application, especially in anti-static environments. Here we employ a facile molding process to fabricate a new type of multi-layered and multi-functional nanocomposite (MMNC), with a tensile strength up to ∼226.4 MPa, a modulus of up to ∼24.8 GPa, a surface electric conductivity of ∼1.2 S cm-1, a water contact angle of ∼155.4° and a water sliding angle of ∼2.0°. These multi-layered and multi-functional nanocomposites (MMNCs) demonstrate robust water-repellency under harsh mechanical abrasion (tested using a high tack sticky tape peel, cyclic sand paper abrasion and even file abrasion) and strong chemical corrosion (tested by using hydrochloric acid, sulfuric acid and sodium hydroxide solutions). Additionally, our MMNCs are highly resistant to water impalement (tested by turbulent water jet impact with a velocity of up to ∼29.5 m s-1 and a corresponding Weber number of ∼32 000). The robustness of the superhydrophobicity is multifaceted, and owing to the excellent structural performance and conductivity, these MMNCs could find potential uses in vehicles, containers, wind blades, infrastructures, electronics and so forth, which usually experience comprehensively harsh conditions such as rainfall, abrasion, static electricity, high loads and so forth.